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Suggest sildenafil plasma concentrations measured after the administration of only one oral dose of 100 mg to healthful male volunteers is depicted underneath:

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The inhibition of PDE5 in Many of these tissues by sildenafil would be the basis for the improved platelet antiaggregatory action of NO observed in vitro, an inhibition of platelet thrombus development in vivo and peripheral arterial-venous dilatation in vivo.

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